Nucleocytoplasmic transport: Driving and directing transport
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چکیده
منابع مشابه
Nucleocytoplasmic transport: Driving and directing transport
Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.
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The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion from, the nucleus, i.e., nuclear import or nuclear export. We consider the operation of this transport system by a combined analytical and exper...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1998
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(98)70239-8